Authors are invited to submit papers for “2nd International Workshop on Quantum Computing: Circuits Systems Automation and Applications (QC-CSAA)” in conjunction with the IEEE Computer Society Annual Symposium on VLSI, July 7-9, 2021. Workshop papers will provide a comprehensive review on fundamentals as well as the current state of the art in research and technology. The purpose of this workshop is to explore design paradigms of quantum computing including developing a full stack from quantum algorithms to quantum chip. Advances in quantum computing hardware, software, and algorithms as well as contributions on the transformative research needed to guide quantum computing performance toward practical and sustainable operations will be aligned with the goal of this workshop. Further, circuits and systems targeting novel and existing applications of quantum computing to fields such as quantum chemistry, linear algebra, scientific applications, aerospace, material science, cryptography, machine learning, etc. will be of special interest.