The Second International Workshop on Programming Languages for Quantum Computing (PLanQC 2021), co-located with PLDI 2021 with be held as a virtual event on June 20-25, 2021. The workshop aims to bring together researchers from the fields of programming languages and quantum information, exposing the programming languages community to the unique challenges of programming quantum computers. It will promote the development of tools to assist in the process of programming quantum computers, both those that exist today and those likely to exist in the near to far future.